Impact of Time-restricted Feeding on Hepatic Steatosis in NAFLD
This is a randomised controlled study of patients with Non-Alcoholic Fatty Liver Disease (NAFLD). Patients will be trained according to the 10 rules of a healthy nutrition according to the German Association for Nutrition (DGE). One arm will undergo Time-Restricted Feeding (TRF) for 12 weeks. The control arm is not subject to any time restrictions concerning eating. It will be investigated whether TRF improves insulin sensitivity, impacts on metabolic inflammation and reduces liver steatosis.
• Age between 18 and 75 years
• Body Mass Index (BMI) \> 25 kg/m2
• Grade 3 steatosis evaluated by with CAP ≥ 300 dB/m and exclusion of known causes of liver steatosis
• Liver elastography \< 13 kPa
• Capability to understand the study and the individual consequences of participation
• Signed and dated declaration of agreement in the forefront of the study